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https://www.texasheart.org/wp-content/uploads/2018/01/Pills.jpg20481367Why do I need to take ACE inhibitors? ACE inhibitors are used to treat congestive heart failure (CHF) and high blood pressure (hypertension). You may also be given ACE inhibitors after you have had a heart attack , because some studies have shown that these medicines may prevent further damage to the heart muscle.